Job Summary:
We are seeking an experienced cell biologist to work with a highly integrated team on the development of a robust drug target discovery platform. The successful candidate will perform analyses on single-cell data to identify interesting candidate genes for follow-up studies – drawing on strong understanding of canonical gene networks and their role in cellular functions.
Candidates for this role will be well versed in the latest cellular and molecular biology knowledge and techniques. In addition, successful candidates must be able to work effectively both in a collaborative setting and independently and possess outstanding written, visual and oral communications skills.
Key Responsibilities:
- Meta-analyses of large-scale data from many experiments cross-referenced against bioinformatics databases and literature to ID interesting candidate genes
- Investigation of candidate genes/pathways via microscopy and/or molecular biology.
- Design and implementation of CRISPR/shRNA mediated dissection of biological networks.
Qualifications and Education Requirements:
You must have:
- PhD in molecular biology, cell biology, genetics, computational biology, or a related field
- Significant experience analyzing NGS data, specifically from RNAseq experiments
- Ability to work with large datasets
- Confocal microscopy for live cell imaging and histology
- Molecular biology techniques: western blotting, northern blotting, qPCR
- Experience with gene expression modulation via CRISPR and/or RNAi
- Demonstrated scientific productivity, as evidenced by strong publication record, and ability to work effectively in a collaborative setting
Additional preferred experience includes:
- Experience with NGS library preparation
- Experience with single-cell methods
- Detailed knowledge of public genomic databases
To Apply
To apply for this position, send us your resume and cover letter to careers@kallyope.com.